2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel
  5. TRPM Isoform
  6. TRPM Inhibitor

TRPM Inhibitor

TRPM Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-149143
    JNJ-28583113
    		Inhibitor 98.06%
    JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia.
  • HY-149999
    Xeniafaraunol A
    		Inhibitor
    Xeniafaraunol A (compound 31) is a potent transient receptor potential melastatin 7 (TRPM7) inhibitor.
  • HY-108461
    TRPM8-IN-1
    		Inhibitor
    TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC50<5 μM.